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Your Questions, Answered – A Deep Dive on the CODEX MAV

In our recent Akoya Academy webinar, “A Deep Dive on the Multiplex Analysis Viewer (MAV) to Analyze CODEX Images”, we heard from Grady Carlson, PhD, Technical Application Scientist at Akoya Biosciences. Grady introduced the CODEX MAV software and its features, including gating, unsupervised clustering, dimensionality reduction plots (e.g., tSNE), and spatial interaction plots and tables. […]

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Customer Spotlight: Using Multiplex IHC in Infectious Disease Research

In a recent paper published in the American Journal of Pathology, researchers from Boston University School of Medicine and collaborators studied temporospatial disease progression in Ebola virus disease (EVD). They used multiplexed fluorescent immunohistochemistry (mIHC) and in situ hybridization to quantify viral and host factors related to Zaire ebolavirus (EBOV) pathogenesis in the liver of […]

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COVID-19: Six Research Highlights and Stories We’re Following

In the past few months, amid the coronavirus outbreak, life has become drastically different for all of us. Many of us have adjusted to staying in our homes, spending much more time than we’re used to with our families, or by ourselves. While the stay-at-home orders being issued across the world may be stressful, they […]

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Implementing CODEX in a Core Lab: A Case Study from ABRF 2020

We were in Palm Springs last week for the Association of Biomolecular Resource Facilities (ABRF) 2020 Annual Meeting. Core lab professionals came together to learn about cutting-edge advances that they can bring to their facilities. Some of this year’s talks revolved around multi-omics, single-cell techniques, and spatial analysis. This reflects scientists’ growing need for analysis […]

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CODEX Software Suite Unlocks the Power of Single-Cell, Spatial Analysis in FFPE Tissue

Single-cell RNA-sequencing methods have become a mainstay tool for cancer researchers. Techniques like CITE-Seq can analyze the expression patterns of large sets of mRNAs and proteins in hundreds or thousands of cells at a time. However, these techniques are hampered by high running costs and incompatibility with FFPE tissues for full transcriptome analysis. Crucially, these […]

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Ask an Expert: A novel approach for spatial multi-omics with single cell resolution

Nature declared single-cell multimodal omics to be the 2019 Method of the Year. This follows the entrenchment of single-cell transcriptome analyses as household tools in biological and clinical research. Single cell transcriptome analyses offer unprecedented access to study cellular heterogeneity and tissue organization, but they remain limited. They provide information solely about the transcriptomic state […]

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Webinar Rewind: Defining the Future of Biomarker Analysis

Biomarker development research follows a continuum, from discovery to translation. At the discovery stage, high plexing capabilities and flexible analysis tools are required. As you move to translational and clinical research, it’s useful to narrow down an assay to something high throughput, standardized, and reproducible. In a webinar featuring Dr. Cliff Hoyt, VP of Translational […]

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Webinar Rewind: Comprehensive Meta-Analysis of Biomarker Technologies

In a paper published in JAMA Oncology, researchers from Johns Hopkins University conducted a systematic review to compare the efficacy of different biomarker modalities in predicting response to PD-1/PD-L1 checkpoint blockade. The researchers found that multiplex immunohistochemistry/immunofluorescence (mIHC/IF) performed significantly higher in measures of diagnostic accuracy for predicting anti-PD-1/PD-L1 therapy when compared to other techniques, […]

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Webinar Rewind: The New Fully Optimized MOTiF™ PD-1/PD-L1 Panel Kits

Developing your own multiplex immunohistochemistry panels can be a challenging, time-consuming process. In our latest webinar, Victoria Duckworth, Product Manager for Opal & TSA Reagents at Akoya Biosciences, introduced our new MOTiF™ PD-1/PD-L1 Panel Kits, which are part of a fully optimized workflow from staining to analysis for lung cancer and melanoma samples.  Using Opal™ […]

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Webinar Rewind: Multiplexed Spatial Analysis for Core Labs

In our recent webinar, we heard from speakers at the Fred Hutchinson Cancer Research Center, who discuss how they successfully implemented and utilize the Vectra® Polaris™ and Vectra® 3 automated, multiplexed tissue imaging platforms in their core lab. Our first speaker was Dr. Savanh Chanthaphavong, the Director of the Experimental Histopathology Core Lab at the Fred Hutchinson […]